863887-89-2

Upstream product

• 863888-33-9 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one 
• 1323347-28-9 2-(t-butyl)-4-chloro-5-[(4-(1,3-dioxolan-2-yl)phenyl)methoxy]-2-hydropyridazin-3-one 
• 109024-00-2 methyl 4-((((1-tert-butyl)-5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)oxy)methyl)benzoate 
• 1323347-23-4 5-((4-(bromomethyl)benzyl)oxy)-2-(tert-butyl)-4-chloropyridazin-3(2H)-one 
• 1323347-22-3 2-(t-butyl)-4-chloro-5-((4-(hydroxymethyl)benzyl)oxy)pyridazin-3(2H)-one 
• 863888-31-7 2-(tert-butyl)-4-chloro-5-((4-((2-hydroxyethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one 
• 863888-30-6 2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone 
• 863888-29-3 {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-phenyl}meyhanol 
• 863888-28-2 4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester 
• 58334-93-3 4-(2-hydroxyethoxymethyl)benzoic acid methyl ester 
• 88093-48-5 2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone 
• 142651-25-0 4-(1',3'-dioxolan-2'-yl)benzyl alcohol 
• 142651-24-9 methyl 4-(1,3-dioxolan-2-yl)benzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 

Relevant academic research and scientific papers

Contrast agent and for the use of a synthetic composition, method and system (by machine translation)

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

COMPOSITIONS COMPRISING ASCORBIC ACID AND AN IMAGING AGENT AND RELATED METHODS

The present invention is generally directed towards compositions comprising ascorbic acid or ascorbate salt and an imaging agent, and related methods. In some embodiments, the imaging agent comprises pyridaben or a pyridaben analog attached to an imaging moiety.

METHODS AND APPARATUS FOR SYNTHESIZING IMAGING AGENTS, AND INTERMEDIATES THEREOF

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comp

Synthesis and biological evaluation of pyridazinone analogues as potential cardiac positron emission tomography tracers

A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be incorporated on an alkyl side chain rather than directly on the pyridazinone moiety. Tissue distribution studies of a series of analogues ([18F] 22-28) in Sprague-Dawley (SD) rats identified [ 18F]27 as the most promising radiotracer with high uptake in cardiac tissue (3.41%ID/g; 30 min post injection) in addition to favorable heart to nontarget organ distribution ratios. MicroPET images of SD rats and nonhuman primates after [18F]27 administration allowed easy assessment of the myocardium through 60 min with minimal lung or liver interference.

Methods of making radiolabeled tracers and precursors thereof

The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. The disc