863891-99-0

Upstream product

• 100-39-0 benzyl bromide 
• 261621-51-6 1‐O‐benzoyl‐scyllo‐inositol 
• 261617-67-8 DL-1-O-mono-benzoyl-(2,3:5,6)-di-O-isopropylidene-scyllo-inositol 

Downstream Products

• 863986-22-5 1-O-benzyl-2,3:5,6-di-O-isopropylidene-scyllo-inositol 
• 863892-00-6 4-O-(1'-imidazolylcarbonyloxy)-2,3:5,6-di-O-isopropylidene-1-O-benzyl-scyllo-inositol 
• 863986-26-9 4'-O-benzyl-1'-O-[(1-O-p-methoxybenzyl-2,3:5,6-di-O-isopropylidene-scyllo-inositol)carbonyloxy]-2',3':5',6'-di-O-isopropylidene-scyllo-inositol 
• 929707-85-7 4'-O-benzyl-1'-O-[(1-O-p-methoxybenzyl-scyllo-inositol)carbonyloxy]-scyllo-inositol 
• 93-58-3 benzoic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis, and delivery properties of novel guanidine-containing molecular transporters built on dimeric inositol scaffolds

We have developed a novel class of synthetic molecular transporters that contain eight residues of guanidine with an inositol dimer as the scaffold. The dimers were prepared by connecting two units of myo- or scyllo-inositol via a carbonate or amide linkage, and the multiple units of the guanidine functionality were constructed on the inositol scaffold by means of peracylation with ω-aminocarboxylate derivatives of varying length. Bioassays based on confocal laser scanning microscopy and fluorescence-activated cell sorter analyses indicated that these transporters display a varying degree of membrane translocating ability, and the intracellular localization and mouse-tissue distribution studies strongly suggested that these transporters undergo substantially different mechanistic processes from those of peptide transporters reported to date. It was also shown that doxorubicin, an anticancer antibiotic, can be efficiently delivered into mouse brain by aid of this type of transporter.

INOSITOL-BASED MOLECULAR TRANSPORTERS AND PROCESSES FOR THE PREPARATION THEREOF

Inositol derivatives in accordance with the present invention are effective in significantly enhancing the transportation of various therapeutic molecules across a biological membrane, which may include the plasma membrane, nuclear membrane or blood-brain barrier.