863917-74-2

Upstream product

• 1027530-47-7 2-(4-chloro-phenyliminomethyleneamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 
• 90543-03-6 4,5,6,7-Tetrahydro-2-(triphenylphosphoranylidenamino)benzothiophen-3-carbonsaeure-ethylester 
• 104-12-1 p-chlorphenylisocyanate 
• 603-35-0 triphenylphosphine 
• 168280-55-5 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

New efficient synthesis of 6,7,8,9-tetrahydro-benzothieno[2,3-d]-1,2,4- triazolo[1,5-a]pyrimidin-10(3H)-ones via a tandem aza-Wittig/heterocumulene- mediated annulation

The carbodiimides 2, obtained from aza-Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with hydrazine to give selectively 3-amino-2-arylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 4. Reactions of 4 with triphenylphosphine, hexachloroethane and Et3N produced iminophosphoranes 5. A tandem aza-Wittig reaction of iminophosphorane 5 with isocyanate, acyl chloride or CS2 generated 6,7,8,9-tetrahydro- benzothieno[2,3-d]-1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-ones 7, 9 or 11 in satisfactory yields. Georg Thieme Verlag Stuttgart.