168280-55-5Relevant academic research and scientific papers
Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines
Al-Taisan, Khulud M.,Al-Hazimi, Hassan M. A.,Al-Shihry, Shar S.
experimental part, p. 3932 - 3957 (2010/09/18)
Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolothienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using
New efficient synthesis of 6,7,8,9-tetrahydro-benzothieno[2,3-d]-1,2,4- triazolo[1,5-a]pyrimidin-10(3H)-ones via a tandem aza-Wittig/heterocumulene- mediated annulation
Ding, Ming-Wu,Huang, Nian-Yu,He, Hong-Wu
, p. 1601 - 1604 (2007/10/03)
The carbodiimides 2, obtained from aza-Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with hydrazine to give selectively 3-amino-2-arylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 4. Reactions of 4 with triphenylphosphine, hexachloroethane and Et3N produced iminophosphoranes 5. A tandem aza-Wittig reaction of iminophosphorane 5 with isocyanate, acyl chloride or CS2 generated 6,7,8,9-tetrahydro- benzothieno[2,3-d]-1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-ones 7, 9 or 11 in satisfactory yields. Georg Thieme Verlag Stuttgart.
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents
Santagati, Maria,Modica, Maria,Santagati,Russo,Spampinato
, p. 7 - 11 (2007/10/02)
New aminothienopyrimidines and derivatives of the new thienotriazolopyrimidine ring system were synthesized to investigate their anticonvulsant activity. The tricyclic compounds 6a, c, e, f, m, o and p and two bicyclic derivatives 4f and 4o were tested. The pharmacological screening results are reported and discussed.
Synthesis, antimicrobial and antiviral evaluation of certain thienopyrimidine derivatives
El-Sherbeny,El-Ashmawy,El-Subbagh,El-Emam,Badria
, p. 445 - 449 (2007/10/02)
A series of 2-substituted amino-3-aminocyclopenteno or cyclohexeno[b]thieno[2,3-d]-3,4-dihydropyrimidin-4-ones has been synthesized by reacting the corresponding thioureido derivatives with hydrazine hydrate. The thienoprimidine analogues obtained were further used to prepare their arylideneamino, thienotriazolopyrimidine or 2-methylthienotriazolopyrimidine derivatives. The prepared compounds were screened for antimicrobial, antiviral and cytotoxic activity. Some of the tested compounds showed promising activity. Detailed syntheses and spectroscopic and biological data are reported.
