863969-93-1Relevant articles and documents
Enantioselective synthesis of (2R,3R)- and (2S,3S)-2-[(3-chlorophenyl)-(2- methoxyphenoxy)methyl]morpholine
Harding, Wayne W.,Hodge, Matthis,Wang, Zhixia,Woolverton, William L.,Parrish, Damon,Deschamps, Jeffrey R.,Prisinzano, Thomas E.
, p. 2249 - 2256 (2007/10/03)
The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantiomers of 1.