863972-75-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 400710-04-5 1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol 
• 863972-73-0 tert-butyl-[1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-enyloxy]-diphenyl-silane 
• 863972-74-1 3-(tert-butyl-diphenyl-silanyloxy)-hex-5-ene-1,2-diol 
• 75-36-5 acetyl chloride 

Downstream Products

• 553665-15-9 (4R,5R)-4,5-Bis-benzyloxy-hept-6-enoic acid (1S,2S)-1-allyl-2-(2-methoxy-ethoxymethoxy)-octyl ester 
• 553665-17-1 (E)-(5R,6R,10S)-5,6-Bis-benzyloxy-10-[(S)-1-(2-methoxy-ethoxymethoxy)-heptyl]-3,4,5,6,9,10-hexahydro-oxecin-2-one 
• 863972-78-5 tert-butyl-{1-[1-(2-methoxy-ethoxymethoxy)-heptyl]-but-3-enyloxy}-diphenyl-silane 
• 863972-77-4 (4S,5S)-4-(tert-Butyl-diphenyl-silanyloxy)-undec-1-en-5-ol 

Relevant academic research and scientific papers

Total synthesis of (-)-microcarpalide from d-mannitol

The total synthesis of the actin-targeting metabolite (-)-microcarpalide is described. Ring-closing metathesis of a dienic ester was used as the key step. d-Mannitol was used as the chiral pool material for the construction of the olefinic acid moiety as well as the olefinic alcohol moiety of the molecule.