864-68-6

Upstream product

• 133343-20-1 3,3'-Dibenzyloxy-4,4'-dimethoxystilben 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 133343-24-5 (1R,2S)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-[(2,2-dimethoxy-ethyl)-methyl-amino]-ethanol 
• 140687-76-9 (1R,2R)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-ethane-1,2-diol 
• 133343-27-8 Acetic acid (1R,2S)-1,2-bis-(3-benzyloxy-4-methoxy-phenyl)-2-[(2,2-dimethoxy-ethyl)-methyl-amino]-ethyl ester 
• 133343-35-8 Acetic acid (R)-((S)-7-benzyloxy-4-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-(3-benzyloxy-4-methoxy-phenyl)-methyl ester 
• 133343-26-7 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide 
• 133343-22-3 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2-oxide 
• 133343-25-6 (S)-7-Benzyloxy-1-[(R)-(3-benzyloxy-4-methoxy-phenyl)-hydroxy-methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol 

Downstream Products

• 485-19-8 (R)-reticuline 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS OF (R)-RETICULINE - A NEW STRATEGY FOR THE ASYMMETRIC SYNTHESIS OF ISOQUINOLINES VIA ENANTIOSELECTIVE EPOXIDATION OR DIHYDROXYLATION

A new strategy for the asymmetric synthesis of 1-benzyl-1,2,3,4-tetrahydroisoquinolines 7 - 9 has been developed.The route involves introduction of asymmetry via enantioselective epoxidation or dihydroxylation of corresponding stilbene precursors followed by aminolysis and Pomeranz-Fritsch cyclization.The strategy has been successfully applied to the asymmetric synthesis of (R)-reticuline (9), the key intermediate in the synthesis of morphine alkaloids on the biomimetic route.