864068-79-1

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE is used as a building block for the synthesis of pharmaceutical drugs, leveraging its unique molecular structure to create new compounds with potential therapeutic effects.
Used in Research and Development for Drug Discovery:
In the realm of drug discovery, TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE is utilized as a key component in the development of new chemical entities. Its ability to modulate biological targets makes it instrumental in the creation of innovative therapeutic agents.
Used in the Production of New Chemical Entities with Therapeutic Effects:
TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE is also employed in the production of new chemical entities that possess potential therapeutic effects. Its integration into these entities is crucial for enhancing their efficacy and safety in treating various medical conditions.
It is essential to handle TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE with care and adhere to proper safety protocols due to its potential reactivity and toxicity, ensuring the safety of both researchers and the environment.

InChI:InChI=1/C14H22N2O3S/c1-14(2,3)19-13(18)16-6-4-10(5-7-16)12-15-11(8-17)9-20-12/h9-10,17H,4-8H2,1-3H3

Upstream product

• 365413-31-6 ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate 
• 214834-18-1 tert-butyl 4-carbamothioylpiperidine-1-carboxylate 
• 922516-53-8 ethyl 2-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)thiazole-4-carboxylate 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 

Downstream Products

• 650579-82-1 1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate 
• 869901-02-0 tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate 
• 1148104-71-5 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole 
• 1259323-15-3 4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidinium chloride 
• 1259322-21-8 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone 
• 1259323-14-2 tert-butyl 4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate 

Relevant academic research and scientific papers

1-(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1-YL)-ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-ethan-l-one derivatives and related compounds as fungicides for crop protection. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 47 to 69; examples 1 to 4; compounds 1 to 81; table 1). An exemplary compound is e.g. 1-(4-(4-(5-(2,6-dichlorophenyl) -4,5-dihydroisoxazol-3-yl)thiazol-2-yl) piperidin-1-yl)-2-((3- methoxypyridin-2-yl)oxy)ethan-1-on ( example 1 ).

1 -(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1 -YL)-ETHAN-1 -ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-1-yl)-ethan-1-one derivatives and related compounds for use as fungicides for crop protection, as well as to a process for preparing the same. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 55 to 94; examples 1 to 4; compounds 1 to 194; table 1).

NOVEL SULFILIMINES OR SULFOXIMINES CONTAINING FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound formula (I) and a process for preparing the same, wherein, R2, A, E, Hy, Ra, n, Q and W1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of formula (I).

NOVEL FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound selected from Formula I and a process for preparing same, wherein R2, T, L1, A, G, J, n, W, Z and Z1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of Formula I.

HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES

The present disclosure relates to a compound of Formula I, wherein the substituents T, A, W, R2, n, Z, G, Z1 and J are as defined in the description.

A class of thiazolidine aldoxime ether compounds and its preparation and use

The invention provides thiazole oxime ether compounds as well as a preparation method and a use thereof. The thiazole oxime ether compounds have chemical structural formulas as shown in formula I in the specification. The invention further discloses structural formulas of the compounds, a synthetic method of the compounds as well as a use of the compounds as pesticides, fungicides, anti-plant virus substances and plant activators, use of the compounds in preventing and controlling diseases, insect pests, mite damages and virus diseases of agriculture, forestry and gardening by combining with additives or synergistic agents acceptable in agriculture and commercial pesticides, miticides, fungicides, anti-plant virus substances and plant activators, and a preparation method of the compounds.

Alpha-amino acrylate microbicide and preparation method and application thereof

The invention provides an alpha-amino acrylate microbicide and a preparation method and application thereof. The alpha-amino acrylate microbicide has a specific chemical structure formula shown as a formula I, and the formula I is shown in the description. The alpha-amino acrylate microbicide has the advantages that by utilizing the design principle of pesticide molecules, a medical leading compound with anti-coronavirus activity is performed with structure modification of agricultural plant virus-resisting activity, a series of alpha-amino acrylate derivatives is designed and synthesized, and particularly, the alpha-amino acrylate derivative containing piperidine ring is synthesized; the known compound is used as a positive reference compound to systematically screen the biology activity; a plurality of high-efficiency anti-virus leading molecules are provided for the developing of new pesticides, and the positive meaning is realized for the reduction application of the pesticide and the protection of environment ecology.

Synthesis of 1,2,3-thiadiazole and thiazole-based strobilurins as potent fungicide candidates

Strobilurin fungicides play a crucial role in protecting plants against different pathogens and securing food supplies. A series of 1,2,3-thiadiazole and thiazole-based strobilurins were rationally designed, synthesized, characterized, and tested against various fungi. Introduction of 1,2,3-thiadiazole greatly improved the fungicidal activity of the target molecules. Compounds 8a, 8c, 8d, and 10i exhibited a relatively broad spectrum of fungicidal activity. Compound 8a showed excellent activities against Gibberella zeae, Sclerotinia sclerotiorum, and Rhizoctonia cerealis with median effective concentrations (EC50) of 2.68, 0.44, and 0.01 μg/mL, respectively; it was much more active than positive controls enestroburin, kresoxim-methyl, and azoxystrobin with EC50 between 0.06 and 15.12 μg/mL. Comparable or better fungicidal efficacy of compound 8a compared with azoxystrobin and trifloxystrobin against Sphaerotheca fuliginea and Pseudoperonspera cubensis was validated in cucumber fields at the same application dosages. Therefore, compound 8a is a promising fungicidal candidate worthy of further development.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

FUNGICIDAL AMIDES

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, insert Formula 1 here wherein R1, R2, A, G, W1, Q, X, Z, and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.