869901-02-0

Basic information

• Product Name: TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• Synonyms: TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate;1-Piperidinecarboxylicacid, 4-(4-forMyl-2-thiazolyl)-, 1,1-diMethylethyl ester;tert-Butyl 4-(4-forMylthiazol-2-yl)piperidine-1-carboxylate;4-(4-Formyl-2-thiazolyl)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
• CAS NO: 869901-02-0
• Molecular Formula: C₁₄H₂₀N₂O₃S
• Molecular Weight: 296.39
• Mol File: 869901-02-0.mol

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 425.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.87±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(869901-02-0)
• EPA Substance Registry System: TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(869901-02-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 869901-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to form complex molecular structures that can exhibit therapeutic properties.
Used in Chemical Research:
In the field of chemical research, TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE serves as a versatile building block for creating novel organic compounds, potentially leading to new discoveries in material science and other related disciplines.

Upstream product

• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 922516-53-8 ethyl 2-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)thiazole-4-carboxylate 
• 365413-31-6 ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate 
• 864068-79-1 tert- butyl 4-(4-(hydroxymethyl)thiazol-2-yl)piperidine-1-carboxylate 

Downstream Products

• 1148104-71-5 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole 

Relevant articles and documents

1 -(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1 -YL)-ETHAN-1 -ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-1-yl)-ethan-1-one derivatives and related compounds for use as fungicides for crop protection, as well as to a process for preparing the same. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 55 to 94; examples 1 to 4; compounds 1 to 194; table 1).

1-(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1-YL)-ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-ethan-l-one derivatives and related compounds as fungicides for crop protection. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 47 to 69; examples 1 to 4; compounds 1 to 81; table 1). An exemplary compound is e.g. 1-(4-(4-(5-(2,6-dichlorophenyl) -4,5-dihydroisoxazol-3-yl)thiazol-2-yl) piperidin-1-yl)-2-((3- methoxypyridin-2-yl)oxy)ethan-1-on ( example 1 ).

NOVEL SULFILIMINES OR SULFOXIMINES CONTAINING FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound formula (I) and a process for preparing the same, wherein, R2, A, E, Hy, Ra, n, Q and W1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of formula (I).

NOVEL FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound selected from Formula I and a process for preparing same, wherein R2, T, L1, A, G, J, n, W, Z and Z1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of Formula I.

HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES

The present disclosure relates to a compound of Formula I, wherein the substituents T, A, W, R2, n, Z, G, Z1 and J are as defined in the description.

A class of thiazolidine aldoxime ether compounds and its preparation and use

The invention provides thiazole oxime ether compounds as well as a preparation method and a use thereof. The thiazole oxime ether compounds have chemical structural formulas as shown in formula I in the specification. The invention further discloses structural formulas of the compounds, a synthetic method of the compounds as well as a use of the compounds as pesticides, fungicides, anti-plant virus substances and plant activators, use of the compounds in preventing and controlling diseases, insect pests, mite damages and virus diseases of agriculture, forestry and gardening by combining with additives or synergistic agents acceptable in agriculture and commercial pesticides, miticides, fungicides, anti-plant virus substances and plant activators, and a preparation method of the compounds.

Alpha-amino acrylate microbicide and preparation method and application thereof

The invention provides an alpha-amino acrylate microbicide and a preparation method and application thereof. The alpha-amino acrylate microbicide has a specific chemical structure formula shown as a formula I, and the formula I is shown in the description. The alpha-amino acrylate microbicide has the advantages that by utilizing the design principle of pesticide molecules, a medical leading compound with anti-coronavirus activity is performed with structure modification of agricultural plant virus-resisting activity, a series of alpha-amino acrylate derivatives is designed and synthesized, and particularly, the alpha-amino acrylate derivative containing piperidine ring is synthesized; the known compound is used as a positive reference compound to systematically screen the biology activity; a plurality of high-efficiency anti-virus leading molecules are provided for the developing of new pesticides, and the positive meaning is realized for the reduction application of the pesticide and the protection of environment ecology.

Synthesis of 1,2,3-thiadiazole and thiazole-based strobilurins as potent fungicide candidates

Strobilurin fungicides play a crucial role in protecting plants against different pathogens and securing food supplies. A series of 1,2,3-thiadiazole and thiazole-based strobilurins were rationally designed, synthesized, characterized, and tested against various fungi. Introduction of 1,2,3-thiadiazole greatly improved the fungicidal activity of the target molecules. Compounds 8a, 8c, 8d, and 10i exhibited a relatively broad spectrum of fungicidal activity. Compound 8a showed excellent activities against Gibberella zeae, Sclerotinia sclerotiorum, and Rhizoctonia cerealis with median effective concentrations (EC50) of 2.68, 0.44, and 0.01 μg/mL, respectively; it was much more active than positive controls enestroburin, kresoxim-methyl, and azoxystrobin with EC50 between 0.06 and 15.12 μg/mL. Comparable or better fungicidal efficacy of compound 8a compared with azoxystrobin and trifloxystrobin against Sphaerotheca fuliginea and Pseudoperonspera cubensis was validated in cucumber fields at the same application dosages. Therefore, compound 8a is a promising fungicidal candidate worthy of further development.