864070-19-9

Basic information

• Product Name: Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-
• Synonyms: Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-;(4-(5-bromo-2-chlorobenzyl)phenoxy)(tert-butyl)dimethylsilane;4-Bromo-1-chloro-2-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]benzene
• CAS NO: 864070-19-9
• Molecular Formula: C₁₉H₂₄BrClOSi
• Molecular Weight: 411.83576
• Mol File: 864070-19-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 411.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.213±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-(864070-19-9)
• EPA Substance Registry System: Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-(864070-19-9)

Safety Data

• Hazardous Substances Data: 864070-19-9(Hazardous Substances Data)

Usage

General Description

"Silane, [4-[(5-bromo-2-chlorophenyl)methyl]phenoxy](1,1-dimethylethyl)dimethyl-" is a complex organic compound that includes elements such as silicon (from silane), bromine, chlorine, and several carbon structures (from phenyl and methyl groups). This chemical can be identified by its unique structure, which includes a silicon atom bonded to a dimethylethyl group, as well as to a phenyl group that is further substituted with a bromo and chlorophenylmethyl arrangement. The applications of this chemical primarily lie in the realm of material science and industrial chemical synthesis, considering the unique reactivity of silane compounds and halogenated aromatic compounds. As a compound, it needs to be handled following specific safety protocols due to its complexity and potential reactivity.

Upstream product

• 333361-51-6 4-bromo-1-chloro-2-(4-methoxybenzyl)benzene 
• 333361-49-2 (5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone 
• 21900-52-7 5-bromo-2-chloro-benzoyl chloride 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 461432-23-5 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene 
• 864070-18-8 4-(5-bromo-2-chlorobenzyl)phenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1204220-63-2 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 912917-83-0 (3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1204219-88-4 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(methoxy-d3)benzyl)-phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 333359-90-3 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204219-27-1 (2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2-d-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204219-68-0 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(ethoxy-1,1-d2)benzyl)-phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204219-80-6 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(ethoxy-d5)benzyl)-phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 864070-37-1 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204220-65-4 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-2-d-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 461432-26-8 dapagliflozin 

Relevant articles and documents

Synthetic method for empagliflozin related substance IMPD

The invention discloses a synthetic method for empagliflozin related substance IMPD. In a current synthetic method of IMPD, a whole synthetic route is longer and the total yield is lower. The synthetic method provided by the invention comprises the following steps: performing hydroxylation by using (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone as a raw material to obtain (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone, performing a reaction by using a carbonyl reducing agent to obtain 4-(5-iodo-2-chlorobenzyl)phenol, protecting phenolic hydroxyl groups by using protecting groups such as TBDMS, performing metallization of aromatic iodide by adopting a relatively stable and safe Grignard reagent i-PrMgCl.LiCl, performing methyl glucoside reduction by using a Lewis acid catalyst, and finally performing quenching to obtain the empagliflozin related substance IMPD. The synthetic method provided by the invention has the advantages of an abundant raw material source, a simple, quick andhigh-efficiency reaction, milder reaction conditions, a higher total yield and low costs.

PROCESS FOR PREPARATION OF DAPAGLIFLOZIN AND INTERMEDIATES THEREOF

Processes for the preparation of dapagliflozin reduce or eliminate impurities in dapagliflozin, preferably individual impurities are not more than 0.15% by HPLC.

NOVEL SGLT INHIBITORS

The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).