86408-08-4

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 104431-77-8 4-(2-fluorophenyl)-2,6-dimethylpyridine 
• 104431-76-7 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid 
• 104431-72-3 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine 
• 104431-82-5 dimethyl 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate 

Relevant academic research and scientific papers

A novel, nonsteroidal inhibitor of androgen binding to the rat androgen binding protein: Diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene]propane dioate

In vitro binding studies demonstrate the binding specificity of a series of 4-aryl-2,6-dimethylpyridines for the rat epididymal androgen binding protein (rABP). The compounds bound competitively to rABP but have very weak or no demonstrable affinity for r

1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach

The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.