864148-39-0Relevant articles and documents
Rhodium-catalyzed asymmetric 1,6-addition of aryl zinc reagents to dienones
Hayashi, Tamio,Yamamoto, Shohei,Tokunaga, Norihito
, p. 4224 - 4227 (2005)
(Chemical Equation Presented) A highly enantioselective methodology allows the preparation of α,β-unsaturated ketones that contain a new stereogenic center at the C5 position. This approach is realized through the title reaction in the presence of chlorotrimethylsilane as a Lewis acid and a rhodium/(S)-binap complex as the catalyst followed by acidic hydrolysis (see scheme). binap = 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl.