864153-25-3Relevant academic research and scientific papers
The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
Brown, Alan D.,Bunnage, Mark E.,Glossop, Paul A.,James, Kim,Jones, Rhys,Lane, Charlotte A.L.,Lewthwaite, Russell A.,Mantell, Simon,Perros-Huguet, Christelle,Price, David A.,Trevethick, Mike,Webster, Rob
, p. 1280 - 1283 (2008/09/19)
The design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using
L-tartrate salt of N-1-Adamantyl-2-{3-[(2R)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl] phenyl}acetamide
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Page/Page column 6; 7, (2008/06/13)
This invention relates to the L-tartrate salt of N-1-Adamantyl-2-{3-[(2R)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl]phenyl}acetamide and its use as a medicament.
Phenylethanolamine derivatives as beta-2 agonists
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Page/Page column 60, (2008/06/13)
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in
