864178-09-6Relevant articles and documents
Triazole oxytocin antagonists: Identification of aryl ether replacements for a biaryl substituent
Brown, Alan,Brown, Lindsay,Brown, T. Bruce,Calabrese, Andrew,Ellis, Dave,Puhalo, Nicholas,Smith, Chris R.,Wallace, Olga,Watson, Lesa
scheme or table, p. 5242 - 5244 (2009/05/07)
Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.
SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS
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Page/Page column 73, (2010/02/13)
The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).