864271-07-8Relevant articles and documents
SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
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Page/Page column 54; 55, (2013/09/12)
The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation
Nirschl, Alexandra A.,Zou, Yan,Krystek Jr., Stanley R.,Sutton, James C.,Simpkins, Ligaya M.,Lupisella, John A.,Kuhns, Joyce E.,Seethala, Ramakrishna,Golla, Rajasree,Sleph, Paul G.,Beehler, Blake C.,Grover, Gary J.,Egan, Donald,Fura, Aberra,Vyas, Viral P.,Li, Yi-Xin,Sack, John S.,Kish, Kevin F.,An, Yongmi,Bryson, James A.,Gougoutas, Jack Z.,DiMarco, John,Zahler, Robert,Ostrowski, Jacek,Hamann, Lawrence G.
supporting information; experimental part, p. 2794 - 2798 (2010/02/28)
A novel selective androgen receptor modulator (SARM) scaffold was discovered as a byproduct obtained during synthesis of our earlier series of imidazolidin-2-ones. The resulting oxazolidin-2-imines are among the most potent SARMs known, with many analogue
BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION
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Page/Page column 31, (2008/06/13)
The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.