864291-36-1

Basic information

• Product Name: 2-chloro-N-(4-chlorobenzyl)-6,7-dimethoxyquinazolin-4-amine
• Synonyms: 2-chloro-N-(4-chlorobenzyl)-6,7-dimethoxyquinazolin-4-amine
• CAS NO: 864291-36-1
• Molecular Weight: 364.231
• Mol File: 864291-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(4-chlorobenzyl)-6,7-dimethoxyquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(4-chlorobenzyl)-6,7-dimethoxyquinazolin-4-amine(864291-36-1)
• EPA Substance Registry System: 2-chloro-N-(4-chlorobenzyl)-6,7-dimethoxyquinazolin-4-amine(864291-36-1)

Safety Data

• Hazardous Substances Data: 864291-36-1(Hazardous Substances Data)

Upstream product

• 27631-29-4 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 
• 104-86-9 4-chlorobenzylamine 

Downstream Products

• 864354-84-7 (1'-{4-[(4-chlorobenzyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4'-bipiperidin-3-yl)methanol 

Relevant articles and documents

Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines

Starting with a series of CC chemokine receptor-4 (CCR4) antagonists developed in a previous study, the potency was improved by replacing the pyrrolidine moiety of N-(4-chlorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine 2 with a 3-(hydroxymethyl)piperidine. The resulting compound (1′-{4-[(4-chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4′-bipiperidin-3-yl)methanol 8ic was a strong inhibitor of human/mouse chemotaxis. Oral administration of 8ic showed anti-inflammatory activity in a murine model of acute dermatitis (oxazolone-induced contact hypersensitivity test) in a dose-dependent manner.