86432-34-0Relevant academic research and scientific papers
Effect of enzyme-substrate interactions away from the reaction site on carboxypeptidase A catalysis
Sebastian, John F.,Liang, Guiqing,Jabarin, Annissa,Thomas, Karen,Wu, H. Bonnie
, p. 290 - 303 (2007/10/03)
The kinetics of 14 peptide substrates of carboxypeptidase A have been studied for the purpose of evaluating P1-P3/S1-S3 interactions. It was found that the amide group at P1-P2 is required
Pharmaceutical composition having an excellent absorption property
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, (2008/06/13)
A compound represented by the formula: STR1 wherein R1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH2 --O-- or --O--CH2 --; R2 is a substituted or unsubstituted phenyl or naphthyl group, or R2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.
Pharmaceutical composition having an excellent absorption property
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, (2008/06/13)
An absorption promoter is disclosed which interacts with hydrophobic amino acid residues of polypeptide derivative medications and substantially increases the absorption of that medication administered orally or rectally. The promoter and medication can b
