864433-04-5Relevant articles and documents
New amides of 5-acylamino-3-methyl-4-isothiazolecarboxylic acid and their immunotropic activity
Lipnicka, Urszula,Regiec, Andrzej,Sulkowski, Emil,Zimecki, Michal
, p. 322 - 328 (2005)
Several new amides 4 of 5-substituted 3-methyl-4-isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino-acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.