864437-22-9

Basic information

• Product Name: Methyl 2-aMino-5-isobutylthiazole-4-carboxylate
• Synonyms: Methyl 2-aMino-5-isobutylthiazole-4-carboxylate;Methyl 2-amino-5-5-isobutylthiazole-4-carboxylate;methyl 2-amino-5-(2-methylpropyl)-1,3-thiazole-4-carboxylate;2-Amino-5-isobutyl-thiazole-4-carboxylic acid methyl ester
• CAS NO: 864437-22-9
• Molecular Formula: C9H14N2O2S
• Molecular Weight: 214.28466
• Mol File: 864437-22-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 2-aMino-5-isobutylthiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-aMino-5-isobutylthiazole-4-carboxylate(864437-22-9)
• EPA Substance Registry System: Methyl 2-aMino-5-isobutylthiazole-4-carboxylate(864437-22-9)

Safety Data

• Hazardous Substances Data: 864437-22-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 17356-08-0 thiourea 
• 590-86-3 isovaleraldehyde 
• 535-15-9 ethyl 1,1-dichloroacetate 

Relevant articles and documents

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives

A series of thiazole-4-carboxylic acid thiazol-2-ylamide (TCAT, 4) derivatives were designed and synthesized according to simple bioisosteric replacement from previously reported pyridine-2-carboxylic acid thiazol-2-ylamide (PCAT) MetAP inhibitors. The preliminary SAR studies demonstrated that these TCAT series of compounds showed different activity and selectivity compared with those of the corresponding PCAT compounds. These findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs.