864448-25-9

Upstream product

• 938-05-6 dibromamine-B 
• 140-88-5 ethyl acrylate 
• 98-10-2 benzenesulfonamide 

Downstream Products

• 1433989-98-0 (1-benzyl-4-(phenylsulfonyl)piperazine-2,6-diyl)dimethanol 
• 335620-96-7 9-benzyl-3-(phenylsulfonyl)-7-oxa-3,9-diaza-bicyclo[3.3.1]nonane 
• 1214249-92-9 3-(phenylsulfonyl)-7-oxa-3,9-diaza-bicyclo[3.3.1]nonane 
• 1214249-93-0 9-methyl-3-(phenylsulfonyl)-7-oxa-3,9-diaza-bicyclo[3.3.1]nonane 
• 868408-12-2 (E)-(5-chloro-2-{3-[9-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-7-yl]-3-oxopropenyl}-phenyl)-carbamic acid tert-butyl ester 
• 868408-15-5 (E)-(5-chloro-2-{3-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-3-oxopropenyl}-phenyl)-carbamic acid tert-butyl ester 
• 868408-04-2 N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide 
• 864448-44-2 9-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester 
• 868408-10-0 2-chloro-1-[9-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-7-yl]-ethanone 
• 868408-06-4 2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone 
• 864448-40-8 9-benzyl-3-oxa-7,9-diazabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester 
• 864448-43-1 7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane 
• 864448-45-3 9-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane 
• 864448-39-5 9-benzyl-3-oxa-7,9-diazabicyclo[3.3.1]nonane 

Relevant academic research and scientific papers

ALKYLATED PIPERAZINE COMPOUNDS

Alkylated piperazine compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Synthesis of novel piperazine based building blocks: 3,7,9-triazabicyclo[3. 3.1]nonane, 3,6,8-triazabicyclo[3.2.2]nonane, 3-oxa-7,9-diazabicyclo[3.3.1] nonane and 3-oxa-6,8-diazabicyclo[3.2.2]nonane

The preparation of four novel bridged piperazine building blocks is described: 3,7,9-triazabicyclo[3.3.1]nonane 1, 3-oxa-7,9-diazabicyclo[3.3.1] nonane 2, 3,6,8-triazabicyclo[3.2.2]nonane 3 and 3-oxa-6,8-diazabicyclo[3.2.2] nonane 4. The scaffold of 1 was