864466-70-6 Usage
Description
S-2-[diphenyl[(triethylsilyl)oxy]Methyl]-Pyrrolidine, also known as DESoxy, is a chemical compound that is a derivative of the neurotransmitter acetylcholine. It is characterized by its potent and selective inhibitory action on the enzyme acetylcholinesterase, which is responsible for the breakdown of acetylcholine in the nervous system. By inhibiting this enzyme, DESoxy effectively increases acetylcholine levels in the brain, thereby enhancing cholinergic neurotransmission. This unique property positions DESoxy as a valuable asset in scientific research and potential therapeutic applications.
Uses
Used in Pharmaceutical Research and Development:
S-2-[diphenyl[(triethylsilyl)oxy]Methyl]-Pyrrolidine is used as a research tool for studying the role of acetylcholine in various neurological processes and disorders. Its ability to modulate acetylcholine levels makes it instrumental in understanding cholinergic neurotransmission and its implications in cognitive function and memory.
Used in Neurodegenerative Disease Treatment:
In the field of neurology, S-2-[diphenyl[(triethylsilyl)oxy]Methyl]-Pyrrolidine is considered for its potential therapeutic use in treating neurodegenerative diseases such as Alzheimer's. By increasing acetylcholine levels, DESoxy may help alleviate some of the cognitive symptoms associated with these conditions, offering a promising avenue for symptom management and disease modification.
Used in the Study of Neurological Disorders:
S-2-[diphenyl[(triethylsilyl)oxy]Methyl]-Pyrrolidine serves as a valuable compound in the investigation of various neurological disorders that involve cholinergic dysfunction. Its use in research settings allows scientists to explore the underlying mechanisms of these disorders and develop targeted interventions.
Used in Drug Development:
In the pharmaceutical industry, DESoxy is utilized in the development of new drugs aimed at treating conditions related to cholinergic deficits. Its role as an acetylcholinesterase inhibitor makes it a key component in the creation of medications designed to improve cognitive function and address memory impairments.
Check Digit Verification of cas no
The CAS Registry Mumber 864466-70-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,4,6 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 864466-70:
(8*8)+(7*6)+(6*4)+(5*4)+(4*6)+(3*6)+(2*7)+(1*0)=206
206 % 10 = 6
So 864466-70-6 is a valid CAS Registry Number.
864466-70-6Relevant articles and documents
Organocatalytic enantioselective α-hydroxymethylation of aldehydes: Mechanistic aspects and optimization
Boeckman, Robert K.,Biegasiewicz, Kyle F.,Tusch, Douglas J.,Miller, John R.
, p. 4030 - 4045 (2015/05/05)
Further studies of the direct enantioselective α-hydroxymethylation of aldehydes employing the α,α-diarylprolinol trimethylsilyl ether class of organocatalysts are described. This process has proven efficient for access to β-hydroxycarboxylic acids and δ-hydroxy-α,β-unsaturated esters from aldehydes in generally good yields, excellent enantioselectivity, and compatibility with a broad range of functional groups in the aldehyde. The goal of these studies was to identify the critical reaction variables that influence the yield and enantioselectivity of the α-hydroxymethylation process such as catalyst structure, pH of the medium, purity of the reactants and reagents particularly with respect to the presence of acidic impurities, and the nature of the buffer, along with the standard variables including solvent, time, temperature and mixing efficiency. The previously identified intermediate lactol has been further characterized and its reactivity examined. These studies have led to identification of the most critical variables translating directly into improved substrate scope, reproducibility, enantioselectivity, and yields.
Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes
Hayashi, Yujiro,Gotoh, Hiroaki,Hayashi, Takaaki,Shoji, Mitsuru
, p. 4212 - 4215 (2007/10/03)
(Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtaine
