86448-86-4Relevant academic research and scientific papers
Unexpected synthesis of N-Acyl indolines via a consecutive cyclization of iminophosphorane
Li, Wen-Jing,Zhao, Fen-Fen,Ding, Ming-Wu
, p. 265 - 267 (2011/03/20)
N-Acyl indolines were obtained unexpectedly from a consecutive cyclization of iminophosphorane in refluxing xylene or 1,2-dichlorobenzene in good yields. This new approach provides an efficient and direct access to the biologically important indolines which are further oxidizable to indoles and oxindoles. Georg Thieme Verlag Stuttgart.
A NEW SYNTHESIS OF AMIDES FROM ACYL FLUORIDES AND N-SILYLAMINES
Rajeswari, Sundaramoorthi,Jones, Robert J.,Cava, Michael P.
, p. 5099 - 5102 (2007/10/02)
Amide bonds are formed readily under mild conditions by the reaction of N-silylamines with the hydrolytically stable acyl fluorides.
REACTION DES NITRONES AVEC LES CHLORURES D'ACIDES: ACTION DE CHLORURES D'ARYL-SULFONYLES ET DU CHLORURE DE BENZOYLE SUR DES N-OXY (ARYL-1 DIHYDRO-3,4 ISOQUINOLEINES). FORMATION D'UNE ISOQUINOLEINE, D'UN ISOCARBOSTYRYLE OU D'UNE INDOLINE SELON LES CONDITIONS
Cherest, M.,Lusinchi, X.
, p. 3471 - 3478 (2007/10/02)
Toluene-p-sulphonyl chloride, p-nitrobenzoyl chloride, and benzoyl chloride react with 1-aryl 3,4-isoquinoline N-oxide depending on the acidity of the medium, the nature of the substituent at C-1, and the nature of the acid chloride, to give an isoquinoline, an isocarbostyril (resulting from the migration of the phenyl substituent at C-1), an indoline (resulting from migration of the phenyl moiety incorporated in the heterocycle), or the formation of an O-acyl hydroxamic acid.The maximum selectivity is obtained in an heterogeneous medium and is governed by the intermediate formation of an hydroxylated pseudo-base.
