864543-75-9Relevant academic research and scientific papers
Synthesis of heteroaryl-fused pyrazoles as P38 kinase inhibitors
Abbot, Sarah C.,Billedeau, Roland J.,Dewdney, Nolan J.,Gabriel, Tobias,Goldstein, David M.,McCaleb, Kristen L.,Soth, Michael,Trejo-Martin, Teresa Alejandra,Zecic, Hasim
experimental part, p. 2811 - 2826 (2010/04/25)
The synthesis of pyrazolo-pyridine, pyrimidine, pyrazine and pyridazine heterocycles is described. In addition, we report the utilization of 2,4-difluorophenoxide as a leaving group, to facilitate formation of the desired pyrazole adducts.
FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS
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Page/Page column 48, (2008/06/13)
Fused pyrazoles effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
Heteroaryl-fused pyrazolo derivatives and methods for using the same
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Page/Page column 49, (2010/02/13)
Compounds of the formula I: where A, B, X, Y, Z, k, R1, R2 and R3 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using t
