298709-29-2

Basic information

• Product Name: 2-Cyano-3,5-difluoropyridine
• Synonyms: 3,5-Difluoropicolinitrile;3,5-Difluoropyridine-2-carbonitrile;3,5-DIFLURO-2-CYANOPYRIDINE;2-Pyridinecarbonitrile,3,5-difluoro-(9CI);3,5-DIFLUORO-2-PYRIDINECARBONITRILE;2-Cyano-3,5-difluoropyridine, 3,5-Difluoropicolinonitrile;2-Cyano-3,5-difluorpyridine;3,5-difluoronicotinonitrile
• CAS NO: 298709-29-2
• Molecular Formula: C₆H₂F₂N₂
• Molecular Weight: 140.09
• EINECS: -0
• Product Categories: HALIDE;PYRIDINE;NITRILE;Pyridine series;Pyridines;API intermediates;Fluorine series
• Mol File: 298709-29-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 32-34°C
• Boiling Point: 187.8 °C at 760 mmHg
• Flash Point: 90℃
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 0.618mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: 0-10°C
• Solubility: soluble in Methanol
• PKA: -5.16±0.20(Predicted)
• CAS DataBase Reference: 2-Cyano-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3,5-difluoropyridine(298709-29-2)
• EPA Substance Registry System: 2-Cyano-3,5-difluoropyridine(298709-29-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 298709-29-2(Hazardous Substances Data)

Usage

Appearance

2-Cyano-3,5-difluoropyridine is a white to Orange to Green powder to crystal.

Uses

2-Cyano-3,5-difluoropyridine is a versatile reactant used in the preparation of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile as antidiabetics.

InChI:InChI=1/C6H2F2N2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H

Upstream product

• 85331-33-5 2-Cyano-3,5-dichloropyridine 

Downstream Products

• 864543-75-9 (3,5-difluoropyridin-2-yl)(2-methoxyphenyl)methanone 
• 1075756-90-9 1-(3,5-difluoropyridin-2-yl)ethan-1-one 
• 1204298-48-5 1-(3,5-difluoropyridin-2-yl)methanamine hydrochloride 
• 1393456-51-3 3,5-bis(4-methoxybenzyloxy)pyridine-2-carbonitrile 
• 1207530-00-4 6-fluoro-1H-pyrazolo[4,3-b]pyridin-3-amine 
• 1227511-52-5 3-fluoro-5-methoxypyridine-2-carboxylic acid 
• 1200605-96-4 (1S)-1-(3,5-difluoropyridin-2-yl)ethanamine (R)-mandelic acid salt 
• 1065267-25-5 1-(3,5-difluoropyridin-2-yl)ethanamine hydrochloride 
• 1075756-92-1 1-(3,5-difluoropyridin-2-yl)ethanol 
• 915720-76-2 rac-1-(3,5-difluoropyridin-2-yl)ethanamine 
• 1065267-14-2 (3,5-difluoro-pyridin-2-yl)-methanol 
• 1378592-49-4 6-fluoro-1H-pyrazolo [4,3-b]pyridine 

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