86456-32-8

Upstream product

• 86456-31-7 1-<<2-(dimethylamino)ethyl>amino>-7-hydroxy-9H-thioxanthen-9-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 108-37-2 1-bromo-3-chlorobenzene 
• 16807-37-7 5-methoxy-2-sulfanyl-benzoic acid 
• 86455-99-4 2-<(3-chlorophenyl)thio>-5-methoxybenzoic acid 
• 86456-05-5 1-<<2-(dimethylamino)ethyl>amino>-7-methoxy-9H-thioxanthen-9-one 

Downstream Products

• 86455-91-6 1-(2-Dimethylaminoethylamino)-7-hydroxy-4-(hydroxymethyl)-9H-thioxanthen-9-one 
• 111324-56-2 1-<<2-(dimethylamino)ethyl>amino>-7-<(tert-butyldiphenylsilyl)oxy>-4-(hydroxymethyl)-9H-thioxanthen-9-one N-methylcarbamate 
• 111324-54-0 1-<<2-(dimethylamino)ethyl>amino>-7-<(tert-butyldiphenylsilyl)oxy>-9-oxo-9H-thioxanthene-4-carboxaldehyde 
• 111324-55-1 1-<<2-(dimethylamino)ethyl>amino>-7-<(tert-butyldiphenylsilyl)oxy>-4-(hydroxymethyl)-9H-thioxanthen-9-one 
• 111324-53-9 1-<<2-(dimethylamino)ethyl>amino>-9-oxo-7-(toluenesulfonyloxy)-9H-thioxanthene-4-carboxaldehyde 
• 101339-44-0 1-<<2-(dimethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one 

Relevant academic research and scientific papers

Preparation and antischistosomal and antitumor activity of hycanthone and some of its congeners. Evidence for the mode of action of hycanthone

The synthesis of a series of esters of hycanthone (HC) and 7-hydroxyhycanthone, their antitumor activity, and their antischistosomal effects on HC-sensitive and HC-resistant schistosomes are reported. Binding studies using tritium-labeled HC and hycanthon

Analogues of hycanthone and lucanthone as antitumor agents

Hycanthone analogues (5 and 6) containing 7-substituted hydroxyl groups were prepared and evaluated as antitumor agents. These compounds were significantly more active than the corresponding unsubtituted derivatives. The 7-hydroxylated-4-(hydroxymethyl)-9H-xanthen-9-ones, 11 and 12, were also active antitumor agents. However, the 7-hydroxy-9H-xanthen-9-one counterparts of the 7-hydroxylucanthones were totally devoid of antitumor activity. Results obtained thus far are consistent with the hypothesis that 4-hydroxymethyl substituents in the 9H-xanthen-9-one and 9H-thioxanthen-9-one series are required for antitumor activity.