86455-99-4

Usage

Chemical Class

Benzoic acids

Core structure

Benzoic acid

Attached groups

3-chlorophenyl group, methoxy group

Usage

Pharmaceuticals, agriculture, chemical research

Biological activities

Anti-inflammatory, antioxidant

Synthesis application

Building block for other organic compounds

Versatility

Diverse applications in scientific and industrial sectors.

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 16807-37-7 5-methoxy-2-sulfanyl-benzoic acid 
• 2037-31-2 3-chlorophenylthiol 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 142-71-2 copper diacetate 
• 584-08-7 potassium carbonate 
• 7440-44-0 pyrographite 

Downstream Products

• 86456-00-0 3-chloro-7-methoxy-9H-thioxanthen-9-one 
• 86456-29-3 1-<<2-(diethylamino)ethyl>amino>-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one 
• 86456-33-9 1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one 
• 101339-44-0 1-<<2-(dimethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one 
• 86456-32-8 1-<<2-(dimethylamino)ethyl>amino>-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one 
• 86455-90-5 1-[[2-(Diethylamino)ethyl]amino]-7-hydroxy-4-(hydroxymethyl)-9H-thioxanthen-9-one 
• 86455-91-6 1-(2-Dimethylaminoethylamino)-7-hydroxy-4-(hydroxymethyl)-9H-thioxanthen-9-one 
• 86456-31-7 1-<<2-(dimethylamino)ethyl>amino>-7-hydroxy-9H-thioxanthen-9-one 
• 86456-01-1 1-chloro-7-methoxy-9H-thioxanthen-9-one 
• 86456-05-5 1-<<2-(dimethylamino)ethyl>amino>-7-methoxy-9H-thioxanthen-9-one 

Relevant academic research and scientific papers

Thioxanthenone antitumor agents

Compounds having anti-tumour activity are disclosed having the formulawherein: (1) n is 2 or 3;R1 and R2 are independently lower-alkyl;Q is a residue chosen from the group consisting ofCH2NHR3, CH2N(R4)SO2R7, CH2NHCHO, CH=N-Ar,C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(C2H5)CHO,CH2N(R4)P(O)(O-lower-alkyl)2, CH2N=CH-N(R9)(R10),CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7;R3 is hydrogen or lower-alkyl;R4 is hydrogen, lower-alkyl or Ar;R5 is hydrogen, lower-alkyl or Ar;R6 is hydrogen or lower-alkyl;R7 is lower-alkyl, or Ar;R8 is hydroxy;Ar is phenyl or phenyl substituted with methyl, methoxy, hydroxy, halogen or nitro; andR9 and R10 are independently lower-alkyl; or(2) Q is a residue chosen from the group consisting of CH2N(R4)SO2R7, CH=N-Ar, C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(R4)P(O)(O-lower-alkyl)2, CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; Ar is phenyl substituted by hydroxy; and n, R1, R2, R4, R5, R6, and R7 are as defined hereinabove in part (1) with the proviso that one or more of R4, R5, or R7 is Ar; or(3) Q is a residue chosen from the group consisting of CH2N=CH-N(R9)(R10) and CH2N(R4)C(O)CF3 ; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; and n, R1, R2, R4, R7, Ar, R9 and R10 are as defined hereinabove in part (1), or a pharmaceutically acceptable acid-addition salt or solvate thereof . Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Lyophilized thioxanthenone antitumor agents

Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a lactate buffer.

Thioxanthenone antitumor agents

1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

7-Hydroxylucanthone, 7-hydroxhycanthone and their analogs

7-Hydroxylucanthone and 7-hydroxyhycanthone derivatives have been found to have significant antitumor effect. The derivatives are of the general formula: STR1 wherein the radicals R1 and R2 are lower alkyl groups or other simple groups and R3 is OH where X=O, and H or OH where X=S.

Analogues of hycanthone and lucanthone as antitumor agents

Hycanthone analogues (5 and 6) containing 7-substituted hydroxyl groups were prepared and evaluated as antitumor agents. These compounds were significantly more active than the corresponding unsubtituted derivatives. The 7-hydroxylated-4-(hydroxymethyl)-9H-xanthen-9-ones, 11 and 12, were also active antitumor agents. However, the 7-hydroxy-9H-xanthen-9-one counterparts of the 7-hydroxylucanthones were totally devoid of antitumor activity. Results obtained thus far are consistent with the hypothesis that 4-hydroxymethyl substituents in the 9H-xanthen-9-one and 9H-thioxanthen-9-one series are required for antitumor activity.