864679-65-2

Upstream product

• 916084-78-1 (2-tert-butoxycarbonylamino-ethyl)-(2-phenylacetylamino-ethyl)-carbamic acid 4-nitro-phenyl ester 
• 55628-82-5 1-(Phenylacetyl)imidazole 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 
• 103-82-2 phenylacetic acid 
• 916084-77-0 [2-(2-phenylacetylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 100-02-7 4-nitro-phenol 

Relevant academic research and scientific papers

Multi-triggered self-immolative dendritic compounds

Novel self-immolative dendritic compounds which have a plurality of cleavable trigger units and hence can release a chemical moiety at their focal point upon a multi-triggering mechanism are disclosed. The novel self-immolative dendritic compounds are gated by a molecular logic gate, being either an AND or OR logic gate and hence can be beneficially used in a variety of biological, chemical and physical applications. Processes of preparing, compositions containing and methods utilizing the novel dendritic compounds are further disclosed.

Prodrug activation gated by a molecular "OR" logic trigger

(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).