86471-16-1

Upstream product

• 86471-15-0 ethyl 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylate 
• 27452-17-1 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene 
• 86471-14-9 ethyl 6-bromo-naphthalene-2-carboxylate 

Relevant academic research and scientific papers

Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and derivatives

Compounds of the formulas: STR1 where X is methyl, methoxy, chlorine, or hydrogen, Y and Y1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR1 R2 where R1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R2 is alkyl with 0 or 1 hydroxy substituent or aryl with the proviso that when Y or Y1 is fluorine, the other Y or Y1 is hydrogen. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

Synthesis and Pharmacological Activity of 6-- and 6-(1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic Acids

6-- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids (4 and 8) have been synthesized and show significant activity in reversing the keratinization process in hamst