864745-74-4Relevant academic research and scientific papers
Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors
Ahmad, Ghufran,Mishra, Pushpesh K.,Gupta, Prasoon,Yadav, Prem P.,Tiwari, Priti,Tamrakar, Akhilesh K.,Srivastava, Arvind K.,Maurya, Rakesh
, p. 2139 - 2143 (2006)
PTPases are considered to be involved in the etiology of diabetes mellitus and neural diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, PTPase inhibitors should be useful tools to study the role of PTPases in these diseases and other biological phenomena, and which can be developed into chemotherapeutic agents. In the present study, we have synthesized novel benzofuran isoxazolines 13-21 via 1,3-dipolar cycloaddition reaction using karanjin (1) and kanjone (2), isolated from Pongamia pinnata fruits. All the synthesized compounds were evaluated against PTPase enzyme. Compounds 19 and 20 displayed significant inhibitory activity with IC50 values 76 and 81 μM, respectively.
An efficient route for commercially viable syntheses of furan- and thiophene-anellated β-hydroxychalcones
Yadav, Prem P.,Ahmad, Ghufran,Maurya, Rakesh
, p. 5621 - 5624 (2007/10/03)
An efficient route for the syntheses of β-hydroxychalcones containing benzofuran and benzothiophene rings is described. Isoxazolines obtained from oxime-olefin cycloadditions were reduced under pressure to a mixture of products. Isoxazoles obtained from C
