864757-75-5

Upstream product

• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 99522-34-6 4-[(tetrahydro-2H-pyran-2-yl)oxy]iodobenzene 

Downstream Products

• 864756-35-4 4-[(4-fluorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one 
• 864757-79-9 4-hydroxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one 
• 864757-74-4 4-(benzyloxy)-1-(4-hydroxyphenyl)pyridin-2(1H)-one 

Relevant academic research and scientific papers

Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists

The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c, exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.

PYRIDONE DERIVATIVE

The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R 1 and R 2 may be same or different and stands for H, etc., or R 1 and R 2 may form an aliphatic nitrogen-containing heterocyclic group together with the N to which they bind; X 1 -X 3 may be same or different and stand for methine or N, provided not all of them simultaneously stand for nitrogen; X 4 -X 7 may be same or different and stand for methine or N, provided that three or more of them do not simultaneously stand for N; Y 1 and Y 3 may be same or different and stand for single bond, -0-, -NR-, -S-, etc ; Y 2 stands for lower lkylene, etc.; R stands for H, etc., L stands for methylene; Z 1 and Z 2 may be same or different and stand for single bond or lower alkylene; or R 1 , L and Z 2 may form an aliphatic nitrogen-containing heterocyclic group with the N to which R 1 binds; and Ar stands for aromatic carbocyclic group, etc.].