864776-35-2

Upstream product

• 101558-80-9 methyl2-(2-aminoethylamino)acetate 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 172405-53-7 methyl [N⁴-(4-methoxytrityl)-cytosin-1-yl]-acetate 
• 172405-52-6 N⁴-[(4-methoxyphenyl)diphenylmethyl]cytosine 
• 94142-97-9 2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione 
• 172405-54-8 [N⁴-(4-methoxytrityl)-cyrosin-1-yl]-acetic acid 
• 861857-04-7 methyl N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)-ethylamino]-ethyl}-glycinate 

Downstream Products

• 682752-98-3 N-{2-[N'⁴-(4-methoxytrityl)-cytosin-1-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine 

Relevant academic research and scientific papers

Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA-peptide conjugates

Peptide nucleic acids have become, arguably, one of the most interesting of DNA mimics. Herein the efficient solution phase synthesis of four novel 1-(4,4-dimethyl-2,6-dioxacyclohexylidene)ethyl/4-methoxytrityl (Dde/Mmt) protected PNA monomers is reported

Full orthogonality between Dde and Fmoc: The direct synthesis of PNA-peptide conjugates

New deprotection conditions for the Dde amine protecting group that are fully orthogonal to Fmoc are described and successfully applied to the dual synthesis of PNA-peptide conjugates.