864875-67-2Relevant academic research and scientific papers
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates
Levin,Chen,Laakso,Du,Du,Venkatesan,Sandanayaka,Zask,Xu,Xu,Zhang,Skotnicki
, p. 4345 - 4349 (2007/10/03)
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1′ group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.
