86489-57-8Relevant academic research and scientific papers
A convenient protocol for the synthesis of hindered aryl malononitriles
Schnyder, Anita,Indolese, Adriano F.,Maetzke, Thomas,Wenger, Jean,Blaser, Hans-Ulrich
, p. 3167 - 3169 (2006)
A technically feasible method has been developed for the synthesis of variety of aryl malononitriles in high yields (70-95%) using the palladium-catalyzed coupling reaction of malononitrile with aryl bromides and chlorides, respectively. The influence a s
Sterically Demanding Oxidative Amidation of α-Substituted Malononitriles with Amines Using O2
Li, Jing,Lear, Martin J.,Hayashi, Yujiro
supporting information, p. 9060 - 9064 (2016/07/26)
An efficient amidation method between readily available 1,1-dicyanoalkanes and either chiral or nonchiral amines was realized simply with molecular oxygen and a carbonate base. This oxidative protocol can be applied to both sterically and electronically challenging substrates in a highly chemoselective, practical, and rapid manner. The use of cyclopropyl and thioether substrates support the radical formation of α-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitrile α-carbanions to afford activated acyl cyanides capable of reacting with amine nucleophiles.
Industrial R&D on catalytic C-C and C-N coupling reactions: A personal account on goals, approaches and results
Blaser, Hans-Ulrich,Indolese, Adriano,Naud, Frederic,Nettekoven, Ulrike,Schnyder, Anita
, p. 1583 - 1598 (2007/10/03)
R&D issues for the application of Pd- and Ni-catalyzed C-C and C-N coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of C-C and C-N coupling for preparative applicatio
A FACILE SYNTHETIC ROUTE TO SOME ARYLMALONONITRILES
Suzuki, Hitomi,Kobayashi, Tsutomu,Osuka, Atsuhiro
, p. 589 - 590 (2007/10/02)
Copper(I) iodide-assisted reaction of aryl iodides with malononitrile anion provides a convenient route to some arylmalononitriles.
