86499-90-3

Upstream product

• 86499-33-4 ethyl 2-amino-4-(2-nitrophenyl)butyrate 
• 86499-31-2 ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(2-nitrophenyl)butanoate 
• 105260-07-9 2-amino-4-(2-nitrophenyl)butyric acid 
• 16793-89-8 (2-bromoethyl)-2-nitrobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 168965-67-1 2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester 
• 168965-66-0 2-<(tert-butoxycarbonyl)amino>-4-(2-aminophenyl)butan-1-ol 
• 153235-12-2 2-<(tert-butoxycarbonyl)amino>-4-(2-nitrophenyl)butan-1-ol 

Relevant academic research and scientific papers

Synthesis, conformation, and biological activity of teleocidin mimics, benzolactams. A clarification of the conformational flexibility problem in structure-activity studies of teleocidins

Tumor-promoter teleocidins and their active congeners (indolactams) are known to exist in an equilibrium between at least two conformational states in solution, the twist and sofa form, due to cis-trans isomerization of the amide bond and the steric effects of substituents on the nine-membered lactam ring. Benzolactam-Vs, in which the indole ring of indolactams is replaced with a benzene ring, were designed and synthesized in an attempt to reproduce the active conformation of teleocidins. Among these benzolactams, eight-membered lactams (benzolactam-V8) can only exist in the twist form, and 9- and 10-membered lactams (benzolactam-V9 and -V10) exist exclusively in the sofa form in solution. The stronger biological activity of benzolactam-V-8-310 than that of indolactam-V (IL-V) and the inactivity of benzolactam-V-9-310 for differentiation inducing activity of HL-60 clearly indicated that the twist form is close to the active conformation of teleocidins.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.