16793-89-8

Basic information

• Product Name: 1-(2-BROMOETHYL)-2-NITROBENZENE
• Synonyms: 2-Nitrophenethyl broMide 97%;1-(2-BROMOETHYL)-2-NITROBENZENE;2-Nitrophenethyl bromide;2-(2-Bromoethyl)nitrobenzene;2-(o-Nitrophenyl)ethyl bromide;o-Nitrophenethyl bromide
• CAS NO: 16793-89-8
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• Product Categories: Building Blocks;Chemical Synthesis;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 16793-89-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 34-38 °C
• Boiling Point: 127-130 °C/1 mmHg
• Flash Point: 125.3°C
• Appearance: /
• Density: 1.562g/cm³
• Vapor Pressure: 0.00538mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-BROMOETHYL)-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOETHYL)-2-NITROBENZENE(16793-89-8)
• EPA Substance Registry System: 1-(2-BROMOETHYL)-2-NITROBENZENE(16793-89-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 16793-89-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 16793-89-8 differently. You can refer to the following data:
1. Reactant for:? ;Reduction at carbon cathodes1? ;N-(ureidoalkyl)benzylpiperidines as CCR3 receptors antagonists2
2. Reactant for:Reduction at carbon cathodesN-(ureidoalkyl)benzylpiperidines as CCR3 receptors antagonists

InChI:InChI=1/C8H8BrNO2/c9-6-5-7-3-1-2-4-8(7)10(11)12/h1-4H,5-6H2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 69628-96-2 p-toluenesulfonic acid o-nitrophenethyl ester 
• 552-89-6 2-nitro-benzaldehyde 
• 579-71-5 2-nitrostyrene 
• 15121-84-3 2-nitro-benzeneethanol 
• 31912-02-4 ethyl 2-nitrophenylacetate 

Downstream Products

• 2001-32-3 3-(2-nitrophenyl)propionic acid 
• 496-15-1 1-indoline 
• 579-71-5 2-nitrostyrene 
• 33100-15-1 2-(2-aminoethyl)nitrobenzene 
• 3478-91-9 dimethyl-(2-nitro-phenethyl)-amine 
• 48148-55-6 N-(o-Nitrophenaethyl)-aethylendiamin 
• 86499-31-2 ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(2-nitrophenyl)butanoate 
• 455260-02-3 4-benzyl-1-[2-(2-nitro-phenyl)ethyl]piperidine 
• 874570-85-1 (1-benzyl-piperidin-4-yl)-[2-(2-nitrophenyl)-ethyl]-amine 
• 455259-97-9 2-[2-(4-benzyl-piperidin-1-yl)ethyl]phenylamine 
• 455260-08-9 2-{2-[4-(4-fluoro-benzyl)piperidin-1-yl]ethyl}phenylamine 
• 105260-07-9 2-amino-4-(2-nitrophenyl)butyric acid 
• 168965-66-0 2-<(tert-butoxycarbonyl)amino>-4-(2-aminophenyl)butan-1-ol 
• 86499-33-4 ethyl 2-amino-4-(2-nitrophenyl)butyrate 

Relevant articles and documents

Direct Arylation of Distal and Proximal C(sp3)-H Bonds of t-Amines with Aryl Diazonium Tetrafluoroborates via Photoredox Catalysis

A visible light-mediated arylation protocol for t-amines has been reported through the coupling of γ- and α-amino alkyl radicals with different aryl diazonium salts using Ru(bpy)3Cl2·6H2O as a photocatalyst. Structurally different 9-aryl-9,10-dihydroacridine, 1-aryl tetrahydroisoquinoline, hexahydropyrrolo[2,1-a]isoquinoline, and hexahydro-2H-pyrido[2,1-a]isoquinoline frameworks with different substitution patterns have been synthesized in good yield using this methodology.

Reduction of 1-(2-Chloroethyl)-2-nitrobenzene and 1-(2-Bromoethyl)-2- nitrobenzene at carbon cathodes: Electrosynthetic routes to 1-nitro-2- vinylbenzene and 1H -indole

Studies of the electrochemical reductions of 1-(2-chloroethyl)-2- nitrobenzene (1) and 1-(2-bromoethyl)-2-nitrobenzene (2) at carbon cathodes in dimethylformamide (DMF) containing tetramethylammonium tetrafluoroborate (TMABF4) have been undertaken. Cyclic voltammograms for 1 and 2 exhibit three irreversible cathodic peaks, the first of which is attributed to one-electron reduction of the nitro group, and the resulting nitro radical-anion immediately reacts as a base with the adjacent alkyl halide moiety via an E2 elimination to produce 1-nitro-2-vinylbenzene. At a potential corresponding to the first cathodic peak, bulk electrolyses of 1 or 2 in the absence of a proton donor afford 1-nitro-2-vinylbenzene as principal product, along with 1H -indole and a dimeric species. However, when 1 or 2 is electrolyzed in the presence of either phenol or 2,4-pentanedione as a proton source, the only significant product is 1H -indole. A mechanistic picture for the reductions of 1 and 2 is proposed, and a separate examination of the electrochemical behavior of 1-nitro-2-vinylbenzene has been included as part of this work.

CGRP receptor antagonists

The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.