86508-37-4

Usage

Class

Cholesterols

Contains

Isopropylseleno group

Molecular weight

482.63 g/mol

Derivative of cholesterol

Contains a selenium atom attached to the isopropyl group

Potential applications in medicinal chemistry and biochemistry

Unique properties conferred by the isopropylseleno group

Potential use in research related to cholesterol metabolism and physiological effects

Further research and studies needed for full understanding of potential uses and implications

InChI:InChI=1/C27H46OSe/c1-18(2)29-16-6-7-19(3)23-10-11-24-22-9-8-20-17-21(28)12-14-26(20,4)25(22)13-15-27(23,24)5/h8,18-19,21-25,28H,6-7,9-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

Upstream product

• 37773-08-3 sodium 2-propaneselenolate 
• 73729-03-0 3β-acetoxy-24-bromochol-5-ene 

Relevant academic research and scientific papers

Synthesis and Evaluation of 24-(Isopropylseleno)chol-5-en-3β-ol

Selenium-75-labeled 24-(isopropylseleno)chol-5-en-3β-ol (4) has been prepared by reaction of sodium isopropylselenol (2) with 3β-acetoxy-24-bromochol-5-ene (3).This new (75)Se-labeled adrenal imaging agent shows pronounced adrenal uptake in rats.The concentration of radioactivity in rat adrenals increased steadily from 1 to 24 h after injection and then decreased slowly over the 21-day period.After 3 days the adrenal/blood and adrenal/liver ratios were 85:1 and 32:1, respectively, which are sufficient for adrenal imaging by single photon techniques.After 6 h the adrenal/blood ratio was 17:1 and the adrenal/liver ratio was 7:1.We propose that these ratios are sufficiently high for positron emission tomography of the adrenals.The absorbed radiation dose values to human organs have been estimated for the (75)Se- and (73)Se-labeled agent.