Journal of Medicinal Chemistry p. 1538 - 1541 (1983)
Update date:2022-08-05
Topics:
Knapp, F. F.
Butler, T. A.
Ferren, L. A.
Callahan, A. P.
Guyer, C. E.
Coffey, J. L.
Selenium-75-labeled 24-(isopropylseleno)chol-5-en-3β-ol (4) has been prepared by reaction of sodium isopropyl<(75)Se>selenol (<(75)Se>2) with 3β-acetoxy-24-bromochol-5-ene (3).This new (75)Se-labeled adrenal imaging agent shows pronounced adrenal uptake in rats.The concentration of radioactivity in rat adrenals increased steadily from 1 to 24 h after injection and then decreased slowly over the 21-day period.After 3 days the adrenal/blood and adrenal/liver ratios were 85:1 and 32:1, respectively, which are sufficient for adrenal imaging by single photon techniques.After 6 h the adrenal/blood ratio was 17:1 and the adrenal/liver ratio was 7:1.We propose that these ratios are sufficiently high for positron emission tomography of the adrenals.The absorbed radiation dose values to human organs have been estimated for the (75)Se- and (73)Se-labeled agent.
View MoreShouguang Nuomeng Chemical Co., Ltd.
Contact:+86-536-5119508/18363669993
Address:Hou Zhen Industrial Park, Shouguang, Shandong, China
BrightGene Bio-Medical Technology Co., Ltd.
website:https://en.bright-gene.com/
Contact:+86-512-62551801
Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Qingdao XinYongAn Chemicals Co., Ltd
Contact:+86-532-81107967
Address:Chengyang dual-port industrial park by the sea,Qingdao
Naturalin Bio-Resource Co., Ltd
website:http://www.naturalin.com
Contact:+86-0731-84430651
Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Improve Medical Technology(Nanxiong) Co., Ltd
Contact:86-751-3836997
Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
Doi:10.1016/j.bmcl.2008.05.067
(2008)Doi:10.1021/jo00167a001
(1983)Doi:10.1016/j.jfluchem.2004.09.026
(2005)Doi:10.1021/ja054503m
(2005)Doi:10.1039/c39880000296
(1988)Doi:10.1039/b507202f
(2005)