86509-36-6

Upstream product

• 19236-58-9 dibenzyl methylphosphonate 
• 74288-34-9 {(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-acetic acid methyl ester 
• 75321-05-0 R,S,R-3-(1'-hydroxyethyl)-2-azetidinone-4-yl acetic acid 
• 74357-70-3 [(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acetic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 538-60-3 dibenzyl hydrogen phosphite 

Downstream Products

• 86509-38-8 (3-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid dibenzyl ester 
• 86509-40-2 {3-[(2S,3R)-3-(1-Hydroxy-ethyl)-4-oxo-azetidin-2-yl]-2-oxo-propyl}-phosphonic acid dibenzyl ester 
• 86509-47-9 [(5S,6R)-6-((S)-1-Hydroxy-ethyl)-3,7-dioxo-1-aza-bicyclo[3.2.0]hept-2-yl]-phosphonic acid dibenzyl ester 
• 86509-49-1 [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-phosphonic acid dibenzyl ester 
• 86530-03-2 {(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,7-dioxo-1-aza-bicyclo[3.2.0]hept-2-yl}-phosphonic acid dibenzyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF CARBAPENEM-3-PHOSPHONIC ACID DERIVATIVES

The synthesis of 6-(1-hydroxyethyl)-2-oxocarbapenem-3-phosphonic acid derivatives, starting from 3-iodomethyl-2-oxoazetidine is described.