86512-60-9

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 67-64-1 acetone 

Downstream Products

• 1407499-52-8 (E)-tert-butyl 3-(3-(2-(4-chlorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 19436-42-1 4-chloro-N'-isopropylbenzohydrazide 
• 92573-97-2 2-(4-chlorophenyl)-2-methoxy-5,5-dimethyl-Δ³-1,3,4-oxadiazoline 

Relevant academic research and scientific papers

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.

Effect of ligand substituents on supramolecular self-assembly and electrochemical properties of copper(II) complexes with benzoylhydrazones: X-ray crystal structures and cyclic voltammetry

Complexation of copper(II) with a series of hetero-donor chelating Schiff bases (HLLR) of para-substituted benzhydrazides (with R = OH, NO 2, CH3O, Cl and tert-butyl substituents) and acetone affords mononuclear [Cu(LLR)2] molecules: 1 [Cu(anbhz)2] (R = NO2); 2 [Cu(ahbhz)2] (R = OH) 3 [Cu(ambhz)2] (R = CH3O); 4 [Cu(acbhz)2] (R = Cl); and 5 [Cu(atbhz)2] (R = tert-butyl). Single-crystal X-ray diffraction results for 2-5 reveal their various supramolecular architectures including 1D and 2D dimensionalities. A detailed analysis of crystal structures allows to gain insight into intermolecular interactions accountable for self-assembly into different networks as well as for various physicochemical properties of the compounds. The major interactions include O-H...N hydrogen bonds (2) as well as CH...N and axial Cu...O (3); π...π stacking (4) and van der Waals CH...C interactions (5). All compounds are characterized by elemental analyses; IR and UV-Vis spectroscopy as well as magnetic susceptibility and cyclic voltammetry measurements. Electrochemical studies reveal the dependence of [Cu(LL R)2]/[Cu(LLR)2]- reduction potentials on substituents of benzoylhydrazonoate ligands.

An efficient synthesis of substituted hydrazides

Routes for the selective synthesis of 1-, or 2-substituted hydrazides, and 1,2-disubstituted hydrazides are reported. These routes proceed via cyanoborohydride reduction of stable acyl hydrazone intermediates. Georg Thieme Verlag Stuttgart.