865133-92-2

Upstream product

• 865234-58-8 C₁₂H₁₃NO₅ 
• 1670-14-0 benzamidine monohydrochloride 
• 1212-53-9 methyl N-benzyloxycarbonylglycinate 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 1095280-99-1 5-benzyloxycarbonylamino-4-chloro-2-phenylpyrimidine 

Relevant academic research and scientific papers

Syntheses of 5-amino-2-phenyl-4(3H)-pyrimidinone derivertives starting with glycine

N-Cbz derivative of 5-amino-2-phenyl-4(3H)-pyrimidinone was prepared from sodium salt of methyl hydroxymethylene glycinate and benzamidine hydrochloride in good yield. However, the reaction with N-substituted benzamidine did not proceed to give the desired pyrimidinone. In contrast, the reaction of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone readily prepared from hippuric acid and N-substituted benzamidine proceeded nicely to give 5-(benzoylamino)-6-oxo-2- phenyl-1(6H)-pyrimidineacetic acid in high yield.

Production method of diaminopyrimidine compounds

The present invention relates to a novel production method of a diaminopyrimidine compound useful as an intermediate for various compounds having a pharmacological activity, a novel intermediate useful for producing said compound, and a production method of the intermediate. The present invention provides a novel 5-aminopyrimidine compound represented by the following formula (2) and a novel 4,5-diaminopyrimidine compound represented by the formula (3), as well as production methods of the compounds of the following formulas (2) to (6). wherein each symbol is as defined in the specification.