86514-41-2

Upstream product

• 86514-39-8 diethyl 2-(2-chloroacetamido)-2-<<2-(N-ethoxycarbonyl-N-phenylamino)phenyl>azo>malonate 
• 86514-36-5 ethyl 2-nitro-N-phenylbenzene-1-carbamate 
• 86514-37-6 ethyl 2-amino-N-phenylbenzene-1-carbamate 
• 86514-40-1 5-(chloromethyl)-1-<2-(N-ethoxycarbonyl-N-phenylamino)phenyl>-1H-1,2,4-triazole-3-carboxylic acid 

Downstream Products

• 86514-42-3 methyl 4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-carboxylate 
• 86514-33-2 4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-methanol 

Relevant academic research and scientific papers

199. Azomalonic Ester Syntheses. Part I. One-Step Synthesis of Triazolobenzodiazepines from Azomalonates. Preparation of Novel Polyaza Tricycles from Diethyl (2-Chloroacetamido)malonate

A useful synthetic principle for the preparation of N-heterocycles consists in the base treatment of azomalonates carrying electrophilic centers in the side chain.Thus, pharmacologically active triazolobenzodiazepine-carboxamides can be prepared in o

NOVEL HETEROCYCLES BY THE MALONIC ESTER VARIATION OF THE JAPP-KLINGEMANN REACTION

Azocompounds prepared by coupling malonic ester derivatives with diazotized anilines, 3-amino-2-chloropyridine, anthranilic ester or 2-aminobenzophenones are shown to be versatile intermediates for the synthesys of various polyaza-heterocycles.