86514-33-2

Upstream product

• 86514-39-8 diethyl 2-(2-chloroacetamido)-2-<<2-(N-ethoxycarbonyl-N-phenylamino)phenyl>azo>malonate 
• 86514-40-1 5-(chloromethyl)-1-<2-(N-ethoxycarbonyl-N-phenylamino)phenyl>-1H-1,2,4-triazole-3-carboxylic acid 
• 86514-41-2 4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-carboxylic acid 
• 86514-36-5 ethyl 2-nitro-N-phenylbenzene-1-carbamate 
• 119-75-5 2-nitro-N-phenylaniline 
• 86514-42-3 methyl 4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-carboxylate 
• 86514-37-6 ethyl 2-amino-N-phenylbenzene-1-carbamate 

Relevant academic research and scientific papers

199. Azomalonic Ester Syntheses. Part I. One-Step Synthesis of Triazolobenzodiazepines from Azomalonates. Preparation of Novel Polyaza Tricycles from Diethyl (2-Chloroacetamido)malonate

A useful synthetic principle for the preparation of N-heterocycles consists in the base treatment of azomalonates carrying electrophilic centers in the side chain.Thus, pharmacologically active triazolobenzodiazepine-carboxamides can be prepared in o

Tricyclic polyazaheterocycles for treating depression or anxiety

The invention relates to novel polycyclic polyazaheterocycles having psychopharmacological properties, especially antidepressive and anxiolytic activity, corresponding to the formula I STR1 in which R1 and R2 each represents, independently of the other, hydrogen, lower alkyl or hydroxy-lower alkyl, or together represent lower alkylene or ethyleneoxyethylene, ethyleneazaethylene or N-lower alkyl- or N-(2-hydroxy-lower alkyl)-ethyleneazaethylene, R3 represents hydrogen or a lower aliphatic hydrocarbon radical or a saturated lower cycloaliphatic hydrocarbon radical or unsubstituted or substituted phenyl, R4 and R5 represent hydrogen or lower alkyl, and Ar represents an unsubstituted or substituted benzo or pyrido radical, and to acid addition salts of compounds of the general formula I, especially the pharmaceutically acceptable acid addition salts of compounds of the general formula I, to pharmaceutical preparations containing these novel substances and to a method of treating conditions of depression or anxiety by administering them.