86525-76-0

Basic information

• Product Name: 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-[(5-methylthiophen-3-yl)oxy]propan-2-ol
• CAS NO: 86525-76-0
• Molecular Formula: C₁₈H₂₅NO₄S
• Molecular Weight: 351.4604
• Mol File: 86525-76-0.mol

Chemical Properties

• Boiling Point: 524.7°C at 760 mmHg
• Flash Point: 271.1°C
• Density: 1.169g/cm³
• Vapor Pressure: 7.74E-12mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-[(5-methylthiophen-3-yl)oxy]propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-[(5-methylthiophen-3-yl)oxy]propan-2-ol(86525-76-0)
• EPA Substance Registry System: 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-[(5-methylthiophen-3-yl)oxy]propan-2-ol(86525-76-0)

Safety Data

• Hazardous Substances Data: 86525-76-0(Hazardous Substances Data)

Upstream product

• 86525-71-5 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane 
• 86525-72-6 1-(5-methyl-3-thienyl) glycerol 
• 29421-92-9 4-bromo-2-methylthiophene 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 86525-73-7 1-(5-methyl-3-thienyloxy)-2,3-epoxypropane 

Relevant articles and documents

Synthesis and β-adrenoceptor blocking activity of thiophenic analogues of toliprolol and bevantolol and closely related compounds

The synthesis of a series of 3-alkylamino-1-thienyloxy-2-propanols starting from isopropylideneglycerol and the corresponding bromothiophene is described. In a preliminary pharmacological study compound 14 is very similar to Propranolol, while compound 13, a thiophenic isoster of Toliprolol seems to be less active. On the other hand compound 15, and isoster of cardioselective Bevantolol appears to be also a cardioselective β-blocking agent.