86525-71-5Relevant academic research and scientific papers
Synthesis and β-adrenoceptor blocking activity of thiophenic analogues of toliprolol and bevantolol and closely related compounds
Conde,Corral,Lissavetzky,et al.
, p. 151 - 154 (2007/10/02)
The synthesis of a series of 3-alkylamino-1-thienyloxy-2-propanols starting from isopropylideneglycerol and the corresponding bromothiophene is described. In a preliminary pharmacological study compound 14 is very similar to Propranolol, while compound 13, a thiophenic isoster of Toliprolol seems to be less active. On the other hand compound 15, and isoster of cardioselective Bevantolol appears to be also a cardioselective β-blocking agent.
