86528-56-5Relevant articles and documents
Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow Fragments
Tomori, Takahito,Nagaoka, Kento,Takeshita, Leo,Shiozawa, Takashi,Miyatake, Yuya,Masaki, Yoshiaki,Sekine, Mitsuo,Seio, Kohji
, p. 8353 - 8363 (2018)
Deoxynucleoside 5′-triphosphate was synthesized with 3-oxo-2H-pyridazin-6-yl (PzO) - a uracil analogue lacking a 2-keto group - as the nucleobase. Theoretical analyses and hybridization experiments indicated that PzO recognizes adeni