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Benzenesulfonyl chloride, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

865305-61-9

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865305-61-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 865305-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,0 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 865305-61:
(8*8)+(7*6)+(6*5)+(5*3)+(4*0)+(3*5)+(2*6)+(1*1)=179
179 % 10 = 9
So 865305-61-9 is a valid CAS Registry Number.

865305-61-9Downstream Products

865305-61-9Relevant articles and documents

Development of a green and sustainable manufacturing process for gefapixant citrate (MK-7264). Part 5: Completion of the api free base via a direct chlorosulfonylation process

Di Maso, Michael J.,Ren, Hong,Zhang, Si-Wei,Liu, Wenjun,Desmond, Richard,Alwedi, Embarek,Narsimhan, Karthik,Kalinin, Alexei,Larpent, Patrick,Lee, Alfred Y.,Ren, Sumei,Maloney, Kevin M.

, p. 2491 - 2497 (2020)

A scalable two-pot sulfonamidation through the process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refractory and unexplained chronic cough. Direct conversion of t

METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS

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Page/Page column 211, (2016/01/25)

Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and

Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases

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Paragraph 0199; 0200, (2015/03/04)

Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formu

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

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Page/Page column 104, (2010/11/26)

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Diaminopyrimidines as P2X3 and P2X2/3 antagonists

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Page/Page column 118, (2010/02/14)

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

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