865355-08-4Relevant academic research and scientific papers
A highly efficient and direct approach for synthesis of enantiopure β-amino alcohols by reductive cross-coupling of chiral N-tert- butanesulfinyl imines with aldehydes
Zhong, Yu-Wu,Dong, Yi-Zhou,Fang, Kai,Izumi, Kenji,Xu, Ming-Hua,Lin, Guo-Qiang
, p. 11956 - 11957 (2007/10/03)
A highly efficient and practical approach for the synthesis of optically pure β-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral β-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure β-amino alcohols that are widely applicable in asymmetric synthesis. Copyright
