865362-74-9 Usage
Uses
FR180204 has been used as ERK inhibitor:to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signalingof extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy
Biochem/physiol Actions
FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
Check Digit Verification of cas no
The CAS Registry Mumber 865362-74-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,6 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 865362-74:
(8*8)+(7*6)+(6*5)+(5*3)+(4*6)+(3*2)+(2*7)+(1*4)=199
199 % 10 = 9
So 865362-74-9 is a valid CAS Registry Number.
865362-74-9Relevant articles and documents
Multi-gram scale synthesis of FR180204
Patnaik, Samarjit,Dietz, Harry C.,Zheng, Wei,Austin, Christopher,Marugan, Juan J.
experimental part, p. 8870 - 8873 (2010/03/01)
(Chemical Equation Presented) A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.