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865362-74-9

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865362-74-9 Usage

Uses

FR180204 has been used as ERK inhibitor:to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signalingof extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Biochem/physiol Actions

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

Check Digit Verification of cas no

The CAS Registry Mumber 865362-74-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,6 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 865362-74:
(8*8)+(7*6)+(6*5)+(5*3)+(4*6)+(3*2)+(2*7)+(1*4)=199
199 % 10 = 9
So 865362-74-9 is a valid CAS Registry Number.

865362-74-9 Well-known Company Product Price

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  • Sigma

  • (SML0320)  FR180204  ≥98% (HPLC)

  • 865362-74-9

  • SML0320-5MG

  • 1,301.04CNY

  • Detail
  • Sigma

  • (SML0320)  FR180204  ≥98% (HPLC)

  • 865362-74-9

  • SML0320-25MG

  • 5,253.30CNY

  • Detail

865362-74-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:865362-74-9 SDS

865362-74-9Upstream product

865362-74-9Downstream Products

865362-74-9Relevant articles and documents

Multi-gram scale synthesis of FR180204

Patnaik, Samarjit,Dietz, Harry C.,Zheng, Wei,Austin, Christopher,Marugan, Juan J.

experimental part, p. 8870 - 8873 (2010/03/01)

(Chemical Equation Presented) A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.

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