865362-95-4Relevant articles and documents
A rapid and convenient synthesis of β-proline
Blanchet, Jér?me,Pouliquen, Mickael,Lasne, Marie-Claire,Rouden, Jacques
, p. 5727 - 5730 (2008/02/09)
A short, reliable, and cheap synthesis of both enantiomers of β-proline, an efficient organocatalyst and an important building block in medicinal chemistry, has been developed in four steps (overall yield: 72%) from the diasteromeric adducts of methyl itaconate and (R)-α-methylbenzylamine. The key step involves the chemoselective reduction of a lactam group in the presence of a benzyl ester.
A convenient and new approach to the synthesis of ω-heterocyclic amino acids from carboxy lactams through ring-chain-transformation. Part 2: Synthesis of (2R)-/(2S)-2-aminomethyl-3-(1-aryl-/1,5-diaryl-1H-pyrazol-3-yl)- propionic acid
Singh, Rakesh K.,Sinha, Neelima,Jain, Sanjay,Salman, Mohammad,Naqvi, Fehmida,Anand, Nitya
, p. 8868 - 8874 (2007/10/03)
Making use of amide activation, a convenient and short path synthesis of optically pure ω-heterocyclic-β-amino acids has been achieved from (1R,3R)- and (1R,3S)-5-oxo-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester. The key step of the synth