865362-95-4

Basic information

• Product Name: (1R,3S)-1-(1-phenyl-ethyl)-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester
• Synonyms: (1R,3S)-1-(1-phenyl-ethyl)-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester
• CAS NO: 865362-95-4
• Molecular Weight: 263.36
• Mol File: 865362-95-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,3S)-1-(1-phenyl-ethyl)-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S)-1-(1-phenyl-ethyl)-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester(865362-95-4)
• EPA Substance Registry System: (1R,3S)-1-(1-phenyl-ethyl)-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester(865362-95-4)

Safety Data

• Hazardous Substances Data: 865362-95-4(Hazardous Substances Data)

Upstream product

• 617-52-7 Dimethyl itakonate 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 99735-46-3 methyl (3S)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate 

Downstream Products

• 865362-97-6 (1R,3S)-5-(2-oxo-2-phenyl-ethylidene)-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester 

Relevant articles and documents

A rapid and convenient synthesis of β-proline

A short, reliable, and cheap synthesis of both enantiomers of β-proline, an efficient organocatalyst and an important building block in medicinal chemistry, has been developed in four steps (overall yield: 72%) from the diasteromeric adducts of methyl itaconate and (R)-α-methylbenzylamine. The key step involves the chemoselective reduction of a lactam group in the presence of a benzyl ester.