865362-97-6Relevant articles and documents
A convenient and new approach to the synthesis of ω-heterocyclic amino acids from carboxy lactams through ring-chain-transformation. Part 2: Synthesis of (2R)-/(2S)-2-aminomethyl-3-(1-aryl-/1,5-diaryl-1H-pyrazol-3-yl)- propionic acid
Singh, Rakesh K.,Sinha, Neelima,Jain, Sanjay,Salman, Mohammad,Naqvi, Fehmida,Anand, Nitya
, p. 8868 - 8874 (2005)
Making use of amide activation, a convenient and short path synthesis of optically pure ω-heterocyclic-β-amino acids has been achieved from (1R,3R)- and (1R,3S)-5-oxo-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester. The key step of the synth